Publications

MOST RECENT PUBLICATIONS (click on paper title to access article) 

Kulikauskas, M.R., X, S., and Bautch, V.L. (2022). The versatility and paradox of BMP signaling in endothelial cell behaviors and blood vessel function. Cell Mol Life Sci. 79(2).

Liu, Z, Ruter DL, Quigley K, Tanke N , Jiang Y, Bautch VL (2021). Single-Cell RNA Sequencing Reveals Endothelial Cell Transcriptome Heterogeneity Under Homeostatic Laminar Flow. Arterioscler Thromb Vasc Biol. 2021 Aug 26. doi:10.1161/ATVBAHA.121.316797 PMID:34433297 Featured article of the issue.

Ruter DL, Liu Z, Ngo KM, X S, Marvin A, Buglak DB, Kidder EJ, Bautch VL (2021). SMAD6 transduces endothelial cell flow responses required for blood vessel homeostasis. Angiogenesis. 2021 May;24(2):387-398.

Buglak DB, Kushner EJ, Marvin AP, Davis KL, Bautch VL. (2020) Excess centrosomes disrupt vascular lumenization and endothelial cell adherens junctions. Angiogenesis. 2020 Nov;23(4), 567–575.

Wylie LA, Mouillesseaux KP, Chong DC, Bautch VL. (2018) Developmental SMAD6 loss leads to blood vessel hemorrhage and disrupted endothelial cell junctions. Dev Biol. 2018 Oct 18;144(2):199-209.

Chong DC, Yu Z, Brighton HE, Bear JE, Bautch VL. (2017) Tortuous Microvessels Contribute to Wound Healing via Sprouting Angiogenesis. Arterioscler Thromb Vasc Biol. 2017 Oct; 37(10):1903-1912.

Yu Z, Ruter DL, Kushner EJ, Bautch VL. (2017) Excess centrosomes induce p53-dependent senescence without DNA damage in endothelial cells. FASEB J. 2017 Jun 16. pii: fj.201601320R.

Boucher JM, Clark RP, Chong DC, Citrin KM, Wylie LA, Bautch VL. (2017) Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis. Nat Commun. 2017 Jun 7;8:15699. ***Recommended in F1000Prime: https://f1000.com/prime/727693164

Bautch VL. (2017) Endoglin moves and shapes endothelial cells. Nat Cell Biol. 2017 May 31;19(6):593-595.

Nesmith JE, Chappell JC, Cluceru JG, Bautch VL. (2017) Blood vessel anastomosis is spatially regulated by Flt1 during angiogenesis. Development. 2017 Mar 1;144(5):889-896.

Lee HW, Chong DC, Ola R, Dunworth WP, Meadows S, Ka J, Kaartinen VM, Qyang Y, Cleaver O, Bautch VL, Eichmann A, Jin SW. (2017) Alk2/ACVR1 and Alk3/BMPR1A Provide Essential Function for Bone Morphogenetic Protein-Induced Retinal Angiogenesis. Arterioscler Thromb Vasc Biol. 2017 Apr;37(4):657-663.

Yu Z, Mouillesseaux KP, Kushner EJ, Bautch VL. (2016) Tumor-Derived Factors and Reduced p53 Promote Endothelial Cell Centrosome Over-Duplication. PLoS One. 2016 Dec 15;11(12):e0168334.

Mouillesseaux KP, Wiley DS, Saunders LM, Wylie LA, Kushner EJ, Chong DC, Citrin KM, Barber AT, Park Y, Kim JD, Samsa LA, Kim J, Liu J, Jin SW, Bautch VL. (2016) Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6. Nat Commun. 2016 Nov 11;7:13247. ***Recommended in F1000Prime: https://f1000.com/prime/726956214

Chappell JC, Cluceru JG, Nesmith JE, Mouillesseaux KP, Bradley VB, Hartland CM, Hashambhoy-Ramsay YL, Walpole J, Peirce SM, Mac Gabhann F, Bautch VL. (2016) Flt-1 (VEGFR-1) coordinates discrete stages of blood vessel formation. Cardiovasc Res. Jul 1;111(1):84-93.

Kushner EJ, Ferro LS, Yu Z, Bautch VL. (2016) Excess centrosomes perturb dynamic endothelial cell repolarization during blood vessel formation. Mol Biol Cell. Jun 15;27(12):1911-20.

Wright CE, Kushner EJ, Du Q, Bautch VL. (2015) LGN Directs Interphase Endothelial Cell Behavior via the Microtubule Network. PLoS One. Sep 23;10(9).

Bautch VL, Caron KM.(2015) Blood and lymphatic vessel formation. Cold Spring Harb Perspect Biol. Mar 2;7(3).

Dudley AC, Bautch VL.(2015) Feeding cancer’s sweet tooth: specialized tumour vasculature shuttles glucose in pancreatic ductal adenocarcinoma. J Pathol. Jun;236(2):133-5. (PDF link)

Boucher JM, Bautch VL. (2014) Antiangiogenic VEGF-A in peripheral artery disease. Nat Med. Dec;20(12):1383-5. (PDF link)

Pelton JC, Wright CE, Leitges M, Bautch VL.(2014) Multiple endothelial cells constitute the tip of developing blood vessels and polarize to promote lumen formation. Development. Nov;141(21):4121-6

Klein KR, Karpinich NO, Espenschied ST, Willcockson HH, Dunworth WP, Hoopes SL, Kushner EJ, Bautch VL, Caron KM. (2014) Decoy receptor CXCR7 modulates adrenomedullin-mediated cardiac and lymphatic vascular development. Dev Cell. Sep 8;30(5):528-40. (PDF link)

Kushner EJ, Ferro LS, Liu JY, Durrant JR, Rogers SL, Dudley AC, Bautch VL. (2014) Excess centrosomes disrupt endothelial cell migration via centrosome scattering. J Cell Biol., 21;206(2):257-72. (PDF link)

Chappell JC, Mouillesseaux KP, Bautch VL. (2013). Flt-1 (vascular endothelial growth factor receptor-1) is essential for the vascular endothelial growth factor-Notch feedback loop during angiogenesis. Arteriosclerosis Thrombosis and Vascular Biology, 33(8), 1952-9. (PDF link) 

Ruhrberg C., & Bautch V.L. (2013). Neurovascular development and links to disease. Cellular and Molecular Life Sciences, 70(10), 1675-84. (PDF link)

Charpentier MS, Christine KS, Amin NM, Dorr KM, Kushner EJ, Bautch VL, Taylor JM, Conlon FL. (2013) CASZ1 promotes vascular assembly and morphogenesis through the direct regulation of an EGFL7/RhoA-mediated pathway. Dev Cell., 29;25(2):132-43. (PDF link)

Kushner EJ, Bautch VL. (2013). Building blood vessels in development and disease. Curr Opin Hematol, 20(3):231-6. (PDF link)

Bautch, V.L. (2012). VEGF-directed blood vessel patterning: from cells to organism. Cold Spring Harbor Perspectives in Medicine, 1;2(9). 

Peirce, S.M., Mac Gabhann, F., & Bautch V.L. (2012). Integration of experimental and computational approaches to sprouting angiogenesis. Current Opinion in Hematology, 19(3), 184-91. (PDF link)

Chappell, J. C., Wiley, D. M., & Bautch, V. L. (2012). How blood vessel networks are made and measured. Cells Tissues Organs, 195(1-2), 94-107. (PDF link)

Sweet, D. T., Chen, Z., Wiley, D. M., Bautch, V. L., & Tzima, E. (2012). The adaptor protein Shc integrates growth factor and ECM signaling during postnatal angiogenesis. Blood, 119(8), 1946-1955. (PDF link)

Wiley, D. M., Kim, J., Hao, J., Hong, C. C., Bautch, V. L., & Jin, S. (2011). Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein. Nature Cell Biology, 13, 686–692. (PDF link)

Chappell, J. C., Wiley, D. M., & Bautch, V. L. (2011). Regulation of blood vessel sprouting. Seminars in Cell & Developmental Biology, 22(9), 1005-1011. (PDF link)

Hashambhoy, Y. L., Chappell, J. C., Peirce, S. M., Bautch, V. L., & Mac Gabhann, F. (2011). Computational modeling of interacting VEGF and soluble VEGF receptor concentration gradients. Frontiers in Computational Physiology and Medicine, 2(62) (PDF link)

Lee, C. Y., & Bautch, V. L. (2011). Ups and downs of guided vessel sprouting: the role of polarity. Physiology, 26(5), 326-333. doi:10.1152/physiol.00018.2011 (PDF link)

Randhawa, P. K., Rylova, S., Heinz, J. Y., Kiser, S., Fried, J. H., Dunworth, W. P., et al. (2011). The Ras activator RasGRP3 mediates diabetes-induced embryonic defects and affects endothelial cell migration.  Circulation Research, 108(10), 1199-1208. (PDF link)

Bautch, V. L. (2011). Stem cells and the vasculature. Nature Medicine, 17, 1437–144. (PDF link)

Bautch, V. L. (2010). Cancer: Tumour stem cells switch sides. Nature, 468, 770–771. (PDF link)

Taylor, S. M., Nevis, K. R., Park, H. L., Rogers, G. C., Rogers, S. L., Cook, J. G., et al. (2010). Angiogenic factor signaling regulates centrosome duplication in endothelial cells of developing blood vessels. Blood, 116(16), 3108-3117. (PDF link)

Chappell, JC, & Bautch, VL. (2010). Vascular development: genetic mechanisms and links to vascular disease. Current Topics in Developmental Biology, 2010, 90, 43-72. (PDF link)

Chappell J.C., Taylor SM, Ferrara N, Bautch VL. (2009). Local guidance of emerging vessel sprouts requires soluble Flt-1. Developmental Cell, 17, 377-386. Cover Photo. (PDF link)

Bautch VL and James JM. (2009). Neurovascular development: The beginning of a beautiful friendship. Cell Adhesion and Migration, 3, 199-204. (PDF link)

Bautch VL. (2009). Endothelial cells form a phalanx to block tumor metastasis. Cell 136, 810-812. (Commentary) (PDF link commentary).

James JM, Gewolb C, Bautch VL. (2009). Neurovascular development uses VEGF-A signaling to regulate blood vessel ingression into the neural tube. Development, 136, 833-841 (PDF link)

Zeng G and Bautch VL. (2009). Differentiation and dynamic analysis of primitive vessels from embryonic stem cells. In Methods in Molecular Medicine, Vol. 482, Regenerative Medicine (eds. J. Audet and W.L. Stanford), pp. 333-344, New Jersey: Humana Press. (PDF link)

Bautch VL. (2008). Ninein leads the way in vessel sprouting. Arteriosclerosis Thrombosis and Vascular Biology, 28, 2094-2095 (Commentary) (PDF link)

Kappas NC*, Zeng G*, Chappell JC, Kearney JB, Hazarika S, Kallianos KG, Patterson C, Annex BH, Bautch VL. (2008). The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching. Journal of Cell Biology, 181, 847-858. * = Co first-authors. (PDF link)

Loureiro RMB, Monaco K-A, Kearney JB, Blickarz-Durand CE, Kirby S, Inamdar MS, Bautch VL. (2008). csf1 is required for early embryonic macrophage development: characterization of the csf1(op)/csf1(op) mutation in ES cell-derived macrophages. British Journal of Haematology, 141, 739-742. (PDF link)

Hartnett ME, Martiniuk D, Sutton DS, Byfield G, Geisen P, Zeng G, Bautch VL. (2008). Neutralizing VEGF decreases tortuosity and alters endothelial cell division orientation in arterioles and veins in a rat model of ROP: relevance to plus disease. Invest Opthalmol Vis Sci, 49, 3107-3114. (PDF link)

Rylova SN, Randhawa PK, Bautch VL. (2008). In vitro differentiation of mouse embryonic stem cells into primitive blood vessels. In Meth Enzymol, Vol. 443, Angiogenesis: In Vitro Systems (ed. D Cheresh), pp. 103-117, San Diego CA: Elsevier Academic Press. (PDF link)

Bautch, VL. (2007). Animal models of vascular development and endothelial cell biology. In Source Book of Models for Biomedical Research, (ed. PM Conn) pp. 355-360, New Jersey: Humana Press.

Kappas, NC and Bautch, VL . (2007). Maintenance and in vitro differentiation of mouse embryonic stem cells to form blood vessels. In Current Protocols in Cell Biology, (ed J.S. Bonifacino et al.). pp. 23.3.1-23.3.20 . John Wiley & Sons, Inc. (PDF link)

Zeng G, Taylor SM, McColm JR, Kappas NC, Kearney JB, Williams LH, Hartnett ME and Bautch, VL . (2007). Orientation of endothelial cell division is regulated by VEGF signaling during blood vessel formation. Blood, 109, 1345-1352. This article was chosen as a Plenary Paper (definitive manuscripts of exceptional scientific importance) and the subject of a commentary: Claesson-Welsh L (2007). Endothelial cells in line. Blood 109, 1343-1344. (PDF link)

Wang, H., Charles, P.C., Wu, Y., Ren, R., Pi, X., Moser, M., Barshishat-Kupper, M., Rubin, J.S., Perou, C., Bautch, V. , and Patterson, C. (2006). Gene expression profile signatures indicate a role for Wnt signaling in endothelial commitment from embryonic stem cells.Circ Res, 98, 1331-1339. (PDF link)

Roberts, D.M., Anderson, A.L., Hidaka, M., Swetenburg, R.L., Patterson, C., Stanford, W.L., and Bautch, V.L. (2004). A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters. Mol Cell Biol, 24, 10515-10528. Cover photo. (PDF link)

Hogan, K.A. and Bautch, V.L. (2004). Blood vessel patterning at the embryonic midline. Curr Topics Dev Biol, 62, 55-85. (PDF link)

Bautch, V.L. , and Ambler, C.A. (2004). Assembly and patterning of vertebrate blood vessels. Trends Cardiovasc Med., 14, 138-143. (PDF link)

Kearney, J.B.*, Kappas, N.C.*, Ellerstrom, C., DiPaola, F.W., and Bautch, V.L. (2004). The VEGF receptor flt-1 (VEGFR-1) is a positive modulator of vascular sprout formation and branching morphogenesis. Blood, 103, 4527-4535. (*= co-first authors). This article and another were subjects of a short commentary: Stacker, SA and Achen, MG. (2004). Inside Blood: VEGF receptors branch into new areas. Blood 103, 4379-4380. (PDF link)

Hogan, K.A.*, Ambler, C.A.*, Chapman, D.L., and Bautch, V.L. (2004). The neural tube patterns vessels developmentally using the VEGF signaling pathway. Development, 131, 1503-1513. (*= co-first authors). This article was the subject of a short commentary: Bradbury, J. (2004). In this issue: hooking up the blood supply, Development 131. (PDF link)

Roberts, D.M., Kearney, J.B., Johnson, J.H., Rosenberg, M.P., Kumar, R., and Bautch, V.L. (2004).The vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR-1) modulates Flk-1 (VEGFR-2) signaling during blood vessel formation. Am. J. Path. 164, 1531-1535. (PDF link)

Kearney, J.B., and Bautch, V.L. (2003). In vitro differentiation of mouse ES cells: hematopoietic and vascular development. In Meth. Enzymol. vol. 365, Differentiation of Embryonic Stem Cells (eds. P.M. Wassarman and G.M Keller), pp. 83-98, San Deigo CA: Elsevier Academic Press.

Ambler, C.A., Schmunk, G.M., and Bautch, V.L. (2003). Stem cell-derived endothelial cells/progenitors migrate and pattern in the embryo using the VEGF signaling pathway. Dev. Biol., 257, 205-219. (PDF link)

Kearney, J.B., Ambler, C.A., Monaco, K-A., Johnson, N., Rapoport, R., and Bautch, V.L. (2002).  Vascular endothelial growth factor receptor Flt-1 negatively regulates developmental blood vessel formation by modulating endothelial cell division. Blood, 99, 2397-2407. Cover photo. (PDF link)

Ambler, C.A., Nowicki, J.L., Burke, A.C., and Bautch, V.L. (2001).  Assembly of trunk and limb blood vessels involves extensive migration and vasculogenesis of somite-derived angioblasts. Developmental Biology, 234, 352-364. (PDF link)

Bautch, V.L., Redick, S. D., Scalia, A., Harmaty, M., Carmeliet, P, and Rapoport, R. (2000).  Characterization of the vasculogenic block in the absence of vascular endothelial growth factor-A. Blood, 95, 1979-1987. (PDF link)