Research Associate (2017 Oct – present)

Post-Doctoral Fellow (2014 Mar – 2017 Oct)
University of North Carolina-Chapel Hill – Department of Pathology and Laboratory Medicine
Principle Investigator: Dr. Li Qian; Study area: direct cardiac reprogramming

Contact Info: ziqing [at] email.unc.edu

Education:
Indiana University (IU), Indianapolis, IN – Ph. D. in Microbiology and Immunology (2013)
University of Science and Technology of China (USTC), Hefei, China – B.S. in Life Science (2008)

Research: Understanding cellular and molecular heterogeneity of endothelial cells in blood vessel formation, homeostasis, and wound healing by utilization of single-cell RNA sequencing and a variety of in vitro cell culture and in vivo animal models.

 

Publications:

Zhou Y, Alimohamadi S, Wang L, Liu Z, Wall JB, Yin C, Liu J, Qian L (2018). A Loss of Function Screen of Epigenetic Modifiers and Splicing Factors during Early Stage of Cardiac Reprogramming. Stem cells international.

Liu Z*, Wang L*, Welch JD*, Ma H, Zhou Y, Vaseghi HR, Yu S, Wall JB, Alimohamadi S, Zheng M, Yin CY, Shen WN, Prins JF, Liu JD, Qian L (2017). Single cell transcriptomics reconstructs lineage conversion from fibroblast to cardiomyocyte. Nature, 551, 100-104 *: co-first author.

Zhou Y, Wang L, Liu Z, Alimohamadi S, Yin CY, Liu JD, Qian L (2017). Comparative gene expression analyses reveal distinct molecular signature between induced cardiomyocytes and induced pluripotent stem cell-derived cardiomyocytes. Cell Report, 20(13), 3014-3024.

Liu Z, Chen O, Wall JB, Zheng M, Zhou Y, Wang L, Vaseghi HR, Qian L, Liu JD (2017). Systematic comparison of 2A peptides for cloning multi-genes in a polycistronic vector. Scientific Reports, 7: 2193.

Liu Z, Chen O, Zheng M, Wang L, Zhou Y, Yin CY, Liu JD, Qian L (2016). Re-patterning of H3K27me3, H3K4me3 and DNA methylation during fibroblast conversion into induced cardiomyocytes. Stem Cell Research. 16 (2), 507–518.

Zhou Y, Wang L, Vaseghi HR, Liu Z, Lu R, Alimohamadi S, Yin CY, Fu JD, Wang GG, Liu JD, Qian L (2016). Bmi1 Functions as a Critical Epigenetic Modulator during Early Phase of Direct Cardiac Reprogramming. Cell Stem Cell, 18 (3), 382-95. Commentary: Herrer D and Benard A. Bmi1-mediated epigenetic signature acts as a critical barrier for direct reprogramming to mature cardiomyocytes. Stem Cell Investigation. 2016 Jul 20; 3-28.

Wang L, Liu Z, Yin C, Zhou Y, Liu J, Qian L (2015). Improved Generation of Induced Cardiomyocytes Using a Polycistronic Construct Expressing Optimal Ratio of Gata4, Mef2c and Tbx5. JoVE (Journal of Visualized Experiments) e53426-e53426.

Wang L*, Liu Z*, Yin C, Asfour H, Chen O, Li Y, Bursac N, Liu J, Qian L (2014). Stoichiometry of Gata4, Mef2c, and Tbx5 influences the efficiency and quality of induced cardiac myocyte reprogramming. Circulation Research, 116 (2), 237-244. *: co-first author. Editorial’s pick of the issue. Editorial: Muraoka N, Ieda M. Stoichiometry of transcription factors is critical for cardiac reprogramming. Circulation Research. 2015 Jan 16; 116: 216-218.

Liu Z, F Zhao, He JJ (2014). Hepatitis C virus (HCV) interaction with astrocytes: non-productive infection and induction of IL-18. Journal of Neurovirology, 20 (3), 278-293

Liu Z, X Zhang, Q Yu, He JJ (2014). Exosome-associated hepatitis C virus in cell cultures and patient plasma. Biochemical and biophysical research communications, 455 (3), 218-222

Liu Z, He JJ (2013). Cell-cell contact-mediated hepatitis C virus (HCV) transfer, productive infection and replication and its requirement for HCV receptors. Journal of Virology, 87(15):8545-58.

Park IW, Ndjomou J, Wen Y, Liu Z, Ridgway ND, Kao CC, He JJ (2013).  Inhibition of HCV Replication by Oxysterol-Binding Protein-Related Protein 4 (ORP4) through Interaction with HCV NS5B and Alteration of Lipid Droplet Formation. Plos One, 8(9):e75648.

Amet T, Ghabril M, Chalasani N, Byrd D, Hu N, Grantham A, Liu Z, Qin X, He JJ, Yu Q (2012). CD59 incorporation protects hepatitis C virus against complement-mediated destruction. Hepatology, 55(2):354-63.

Zhan J, Ding B, Ma R, Ma X, Su X, Zhao Y, Liu Z, Wu J, Liu H (2010). Develop reusable and combinable designs for transcriptional logic gates. Molecular Systems Biology, 6:388.